鉴于过敏性疾病的发生率持续上升,膳食模式的改变被认为是导致这些疾病出现和进展的一个可能因素.目前,人们非常关注利用具有抗过敏特性的天然化合物的饮食疗法的开发。膳食多酚和植物代谢物由于其有据可查的抗炎作用而得到了深入研究,抗氧化剂,和免疫调节特征,使它们成为最突出的天然生物活性化学物质之一。这项研究旨在讨论这些分子可能发挥抗过敏作用的深入机制,即通过它们减少蛋白质过敏性的能力,调节免疫反应,并改变肠道微生物群的组成。然而,需要进一步调查才能充分了解这些影响。本文研究了来自实验和临床研究的现有证据,这些证据支持以下观点:不同的多酚,比如儿茶素,白藜芦醇,姜黄素,槲皮素,和其他人,可以减少过敏性炎症,缓解食物过敏的症状,哮喘,特应性皮炎,和过敏性鼻炎,并防止过敏性免疫反应的进展。总之,膳食多酚和植物代谢物具有显著的抗过敏特性,可用于开发针对过敏性疾病的预防和治疗策略。本文还讨论了多酚研究和广泛使用的制约因素,以及未来研究的潜在途径。
Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic
dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.